{"id":4646,"date":"2026-02-27T12:03:47","date_gmt":"2026-02-27T12:03:47","guid":{"rendered":"https:\/\/cnete.qc.ca\/?page_id=4646"},"modified":"2026-02-27T17:20:37","modified_gmt":"2026-02-27T22:20:37","slug":"industrial-bioprocesses-scale-up-training-program","status":"publish","type":"page","link":"https:\/\/cnete.qc.ca\/en\/industrial-bioprocesses-scale-up-training-program\/","title":{"rendered":"Industrial Bioprocesses Scale-Up Training Program"},"content":{"rendered":"

[et_pb_section fb_built=”1″ _builder_version=”4.27.4″ _module_preset=”default” custom_padding=”||5px|||” global_colors_info=”{}”][et_pb_row _builder_version=”4.27.5″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.27.5″ _module_preset=”default” global_colors_info=”{}”][et_pb_image src=”https:\/\/cnete.qc.ca\/wp-content\/uploads\/2026\/02\/Formation_Scaling_Up_Industrial_Bioprocesses-v1.png” title_text=”Formation_Scaling_Up_Industrial_Bioprocesses-v1″ _builder_version=”4.27.5″ _module_preset=”default” min_height=”689px” custom_margin=”|110px||||” custom_padding=”|31px|0px|||” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” width=”56.8%” module_alignment=”center” custom_margin=”|285px||auto||” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.5″ _module_preset=”default” border_color_all=”#7CDA24″ global_colors_info=”{}”]<\/p>\n

CNETE offers training in industrial bioprocesses, focused on scaling up fermentative bioprocesses to advance toward commercialization.<\/h3>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.27.4″ _module_preset=”default” custom_padding=”0px|2px|3px|||” global_colors_info=”{}”][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” custom_margin=”|auto|-69px|auto||” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.5″ _module_preset=”default” custom_padding=”0px||0px|||” global_colors_info=”{}”]<\/p>\n

REGISTRATION DEADLINE: April 3rd, 2026<\/strong><\/p>\n

\n

FEES<\/strong><\/p>\n

Theoretical training<\/strong> (online), followed by practical training<\/strong> (at CNETE in Shawinigan) | Includes PDF training documents for all covered modules, as well as a printed copy of the bioreactor assembly protocols, bioprocess start\u2011up procedures, analytical methods, a checklist, and a data entry table.<\/p>\n

The training will be held only if a sufficient number of participants register. If the number of participants is insufficient to start a cohort, any payments already made will be refunded, if applicable.<\/p>\n

IMPORTANT<\/strong><\/span><\/p>\n

DATE OF THE NEXT COHORT:<\/strong> Starts Friday, April 10th, 2026<\/em><\/span>
DATES:<\/strong> The theory portion will take place in four 4\u2011hour blocks, one per week (8:30 a.m. to 12:30 p.m.), online, from April 10th to May 1st, 2026.<\/p>\n

The practical portion is delivered over two and a half days<\/strong> in at CNETE’s facilities, in Shawinigan, QC, following consultations with registered participants. Indicative target dates: first two weeks of June.<\/p>\n

PRICING
Theory (online): <\/strong>Regular – $1,500<\/strong> \/ Student – $1,000
Practice (on-site in Shawinigan, QC): Regular – $3,750 \/ Student – $3,000<\/strong><\/p>\n

A $250 rebate will be applied for a registration in both theory and practical training.<\/p>\n

A registration is considered confirmed only once payment has been received.<\/p>\n

Accepted payment methods:<\/strong> cheque or bank transfer only.<\/p>\n

For any questions: Nicholas Berrouard (nberrouard@cnete.qc.ca) \/ Nicolas Viau (nviau@cnete.qc.ca).<\/p>\n<\/div>\n

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[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” custom_margin=”|auto||311px||” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_heading title=”REGISTRATION FORM” url=”https:\/\/cnete.qc.ca\/wp-content\/uploads\/2026\/02\/Registration-Form-Bioprocesses-Scale-Up-Training-2026-v1.pdf” _builder_version=”4.27.5″ _module_preset=”default” title_level=”h3″ title_text_align=”center” box_shadow_style=”preset5″ text_shadow_style=”preset1″ text_shadow_color=”#7CDA24″ global_colors_info=”{}”][\/et_pb_heading][et_pb_heading title=”DESCRIPTION” _builder_version=”4.27.4″ _module_preset=”default” title_text_align=”center” global_colors_info=”{}”][\/et_pb_heading][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” custom_padding=”6px|||||” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.5″ _module_preset=”default” hover_enabled=”0″ global_colors_info=”{}” sticky_enabled=”0″]<\/p>\n

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CNETE has recently developed an entirely new theoretical and practical training program on the scale\u2011up of microbial fermentation processes, in response to a growing demand from companies, industries, graduate students, research centers, government laboratories, and others working directly or indirectly in the field of biotechnology\u2014and more specifically in industrial bioprocessing.<\/p>\n

Scaling up a fermentation process remains relatively unknown and is complex to execute. Many companies encounter difficulties during this phase, as they are often not adequately prepared to face this major challenge.<\/p>\n

This new training, will go further than CNETE’s other bioprocesses program, which focuses on the basics, emphasizing instead the critical aspects of scale\u2011up, common pitfalls to avoid, and intelligent ways to navigate the issues encountered.<\/p>\n

It is intended both for individuals who completed basic bioprocess training and for experienced personnel in microbial fermentation who wish to enhance their theoretical and practical knowledge. This training will be offered in Fall 2025.<\/p>\n<\/div>\n

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[\/et_pb_text][et_pb_heading title=”OUR INSTRUCTORS” _builder_version=”4.27.5″ _module_preset=”default” title_text_align=”center” min_height=”51px” custom_margin=”||12px|||” global_colors_info=”{}”][\/et_pb_heading][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.5″ _module_preset=”default” global_colors_info=”{}”]<\/p>\n

 <\/p>\n

With more than 60 years of combined experience<\/strong> in bioprocesses, Denis Groleau, PhD<\/strong> (Universit\u00e9 de Sherbrooke), and Louis Tessier, PhD<\/strong> (C\u00e9gep de Shawinigan \/ CNETE), are experts who will not only convey the essential concepts but also stimulate your thinking!<\/div>\n

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[\/et_pb_text][et_pb_heading title=”Denis Groleau, PhD” _builder_version=”4.27.4″ _module_preset=”default” title_level=”h2″ title_text_align=”left” locked=”off” global_colors_info=”{}”][\/et_pb_heading][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_3,2_3″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”1_3″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_image src=”https:\/\/cnete.qc.ca\/wp-content\/uploads\/2024\/04\/Denis-Groleau.png” title_text=”Denis Groleau” _builder_version=”4.27.4″ _module_preset=”default” width=”99.2%” module_alignment=”center” min_height=”371px” custom_margin=”|-52px|41px|||” custom_padding=”||0px|||” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][et_pb_column type=”2_3″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.5″ _module_preset=”default” global_colors_info=”{}”]<\/p>\n

Adjunct professor at Universit\u00e9 de Sherbrooke, consultant and collaborator at CNETE.<\/strong><\/span><\/p>\n

Experience<\/strong><\/p>\n

    \n
  • Research officer at Biotechnology Research Institute, Biochemical Engineering Section, and<\/li>\n
  • Microbial Fermentation Pilot Plant (NRC, Montreal) 1987-2012<\/li>\n
  • Mounting and giving a training program dealing with pilot-scale microbial fermentation and primary recovery (1992-1995)<\/li>\n
  • Professor-researcher at Universit\u00e9 de Sherbrooke (Faculty of Engineering) as a Tier 1 Canada Research Chair holder (2012-2021)<\/strong><\/li>\n<\/ul>\n

    Research skills<\/strong><\/p>\n

      \n
    • Various groups of microorganisms including genetically engineered ones<\/li>\n
    • Biopolymers, technical or pharmaceutical enzymes, recombinant peptides and proteins, microbial inoculants, vaccines, vaccine adjuvants, plasmids, etc.<\/li>\n
    • Technologies of bioreactors<\/li>\n<\/ul>\n

      [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_heading title=”Louis Tessier, PhD” _builder_version=”4.27.4″ _module_preset=”default” title_level=”h2″ global_colors_info=”{}”][\/et_pb_heading][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_3,1_3,1_3″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”1_3″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_image src=”https:\/\/cnete.qc.ca\/wp-content\/uploads\/2024\/04\/LouisTessier.jpg” title_text=”LouisTessier” _builder_version=”4.27.4″ _module_preset=”default” width=”100%” module_alignment=”center” custom_margin=”|-52px|-5px|||” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.5″ _module_preset=”default” custom_margin=”|||-368px||” custom_padding=”|||0px||” global_colors_info=”{}”]<\/p>\n

      Professor at C\u00e9gep de Shawinigan, and associate researcher at CNETE<\/p>\n

      Experience<\/strong><\/p>\n

        \n
      • Professor at the department of biology and biotechnologies since 2000 (Laboratory Techniques in Biotechnology and the Natural Sciences programs)<\/li>\n
      • Teacher of the Industrial Bioprocess course for the last 23 years (wrote a book in French used by colleges and universities)<\/li>\n
      • Conducting applied researches in industrial bioprocesses at the CNETE<\/li>\n<\/ul>\n

        Research skills<\/strong><\/p>\n

          \n
        • Optimization of culture medium, fermentation conditions, modes of fermentation with wildtype and recombinant strains, scaling-up bioprocesses<\/li>\n
        • Purification technologies (membrane filtration, continuous centrifugations, chromatography, distillation, freeze and spray-drying, precipitation, etc.)<\/li>\n
        • Biosurfactants, biopolymers, fragrances, exoenzymes, proteins, fatty and organic acids\u2026<\/li>\n
        • Bioreactor technologies<\/li>\n<\/ul>\n

          [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.27.4″ _module_preset=”default” custom_padding=”12px|||||” global_colors_info=”{}”][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” min_height=”105px” custom_margin=”|auto|-12px|auto||” custom_padding=”9px||14px|||” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_heading title=”TRAINING CURICULUM” _builder_version=”4.27.5″ _module_preset=”default” custom_margin=”||5px|||” global_colors_info=”{}”][\/et_pb_heading][et_pb_heading title=”Intensive Theory (online)” _builder_version=”4.27.5″ _module_preset=”default” title_level=”h3″ global_colors_info=”{}”][\/et_pb_heading][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” custom_padding=”10px|||||” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.5″ _module_preset=”default” text_font_size=”16px” custom_margin=”0px|||0px|false|false” custom_padding=”0px||0px||false|false” global_colors_info=”{}”]<\/p>\n

          Online training in bioprocessing<\/strong>, with a focus on the different stages of microbial fermentation. The content covers:<\/h3>\n

           <\/p>\n

            \n
          • What is scale\u2011up: objectives and expectations?<\/strong><\/li>\n<\/ul>\n
            \n
              \n
            • \n
                \n
              • Classical scale\u2011up approaches and their associated objectives and targets, golden rules to follow, and the sequence of key steps. Comparison between pilot\u2011scale and industrial\u2011scale operations. Industrial context and realities of scale\u2011up. Reverse scale\u2011up.<\/li>\n<\/ul>\n<\/li>\n
              • Pilot and industrial bioreactors<\/strong>\n
                  \n
                • Tank geometry and design of large\u2011scale bioreactors, control systems for large\u2011scale fermentation parameters, agitation and aeration systems, in\u2011place sterilization (SIP) of bioreactors and peripheral components, pumps, piping, valves, tubing, and sampling. Tank pressurization and single\u2011use systems.<\/li>\n<\/ul>\n<\/li>\n
                • Key aspects of scale\u2011up<\/strong>\n
                    \n
                  • Preparation of an industrial stock culture (strain), development of sequential inoculum trains (seed train), procurement, handling, and control of raw materials, large\u2011scale media preparation and sterilization, fermentation parameters to consider during scale\u2011up (temperature control, mixing and fluid dynamics, O\u2082 transfer and aeration, partial pressure, feeding strategies such as fed\u2011batch, etc.). Criteria used during scale\u2011up (agitation power, impeller tip speed, mixing time, aeration rate and gas velocity, heat transfer rate, etc.). Examples of recommended guidelines for pilot\u2011scale trials aimed at supporting scale\u2011up.<\/li>\n<\/ul>\n<\/li>\n
                  • Evaluating scale\u2011up success<\/strong>\n
                      \n
                    • Productivity, yield, growth profile, operational performance (process control, reproducibility), product quality, storage and stability, and economic viability.<\/li>\n<\/ul>\n<\/li>\n
                    • Causes of scale\u2011up failures<\/strong>\n
                        \n
                      • Operational constraints, unrealistic scale\u2011up factors, inadequate mixing, imprecise control loops, microbial contamination, genetic instability of the strain, raw material and water quality, ineffective feeding strategies.<\/li>\n<\/ul>\n<\/li>\n
                      • Common scale\u2011up mistakes<\/strong>\n
                          \n
                        • Frequent scale\u2011up errors, insufficient or misaligned funding and investment, poor time management, lack of focus, and more.<\/li>\n<\/ul>\n<\/li>\n
                        • Cost considerations and economic analysis<\/strong>\n
                            \n
                          • Capital investment, operating costs and optimization, return on investment and economic viability, with examples.<\/li>\n<\/ul>\n<\/li>\n
                          • Safety and regulatory aspects<\/strong>\n
                              \n
                            • Production standards depending on the intended use (GLP, GMP, HACCP, ISO 22000, DMF, etc.), and best practices for large\u2011scale operations.<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/div>\n

                              [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” min_height=”105px” custom_margin=”|auto|-12px|auto||” custom_padding=”9px||14px|||” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_heading title=”Practical Training (on site at CNETE, in Shawinigan, QC)” _builder_version=”4.27.5″ _module_preset=”default” title_level=”h3″ global_colors_info=”{}”][\/et_pb_heading][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” custom_margin=”-33px|auto||auto||” custom_padding=”10px|||||” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.5″ _module_preset=”default” text_font_size=”16px” custom_margin=”0px|||0px|false|false” custom_padding=”0px||0px||false|false” global_colors_info=”{}”]<\/p>\n

                              \u200bHands\u2011on intensive training at CNETE facilities over two and a half days:<\/strong><\/h3>\n
                              \n

                              Intensive workshop on the operation of a 40 L bioreactor (inoculum) and a 700 L pilot\u2011scale bioreactor using a recombinant strain producing an enzyme used in genetic engineering.<\/strong><\/h3>\n
                                \n
                              • Preparation and start\u2011up of an inoculum<\/strong> in a 40 L bioreactor.<\/li>\n
                              • Preparation of a culture medium and feed medium<\/strong>, assembly and sterilization of a 700 L bioreactor and its peripheral components (feed tanks, piping, aeration system, etc.), and verification of sterility.<\/li>\n
                              • Identification of key components and control systems<\/strong> of the 700 L bioreactor.<\/li>\n
                              • Introduction to the 700 L bioreactor control software<\/strong> (manual and automated control of valves, pumps, and agitation motor, monitoring of fermentation parameters).<\/li>\n
                              • Execution of a multi\u2011step in\u2011place sterilization (SIP) strategy:<\/strong> sterilization of the vessel with medium, sterilization of a separate feed medium, sterilization of side tanks (acid, base, antifoam), and individual sterilization of access lines to the vessel.<\/li>\n
                              • Fermentation start\u2011up<\/strong> (inoculation using broth from the 40 L bioreactor), monitoring and sampling.<\/li>\n
                              • Optical density analysis<\/strong> and preparation of samples for HPLC sugar analysis<\/strong>.<\/li>\n
                              • Harvesting of the fermentation broth<\/strong>, disassembly and cleaning of the bioreactor, and sensor maintenance<\/strong>.<\/li>\n<\/ul>\n<\/div>\n

                                 <\/p>\n

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